Chondroitin sulfate proteoglycans: structure-function relationship with implication in neural development and brain disorders.
Speranta AvramSergey ShaposhnikovCătălin BuiuMaria MerneaPublished in: BioMed research international (2014)
Chondroitin sulfate proteoglycans (CSPGS) are extracellular matrix components that contain two structural parts with distinct functions: a protein core and glycosaminoglycan (GAG) side chains. CSPGs are known to be involved in important cell processes like cell adhesion and growth, receptor binding, or cell migration. It is recognized that the presence of CSPGs is critical in neuronal growth mechanisms including axon guidance following injury of nervous system components such as spinal cord and brain. CSPGs are upregulated in the central nervous system after injury and participate in the inhibition of axon regeneration mainly through their GAG side chains. Recently, it was shown that some CSPGs members like aggrecan, versican, and neurocan were strongly involved in brain disorders like bipolar disorder (BD), schizophrenia, and ADHD. In this paper, we present the chemical structure-biological functions relationship of CSPGs, both in health state and in genetic disorders, addressing methods represented by genome-wide and crystallographic data as well as molecular modeling and quantitative structure-activity relationship.
Keyphrases
- bipolar disorder
- extracellular matrix
- genome wide
- cell migration
- resting state
- spinal cord
- white matter
- cell adhesion
- cerebral ischemia
- functional connectivity
- major depressive disorder
- healthcare
- structure activity relationship
- stem cells
- dna methylation
- public health
- binding protein
- spinal cord injury
- mental health
- attention deficit hyperactivity disorder
- autism spectrum disorder
- electronic health record
- cell therapy
- mesenchymal stem cells
- brain injury
- mass spectrometry
- gene expression
- cerebrospinal fluid
- transcription factor
- risk assessment
- artificial intelligence
- amino acid