Photoinduced remote regioselective radical alkynylation of unactivated C-H bonds.

A method for the remote regioselective alkynylation of unactivated C(sp 3 )-H bonds in diverse aliphatic amides by photogenerated amidyl radicals has been developed. The site-selectivity is dominated via a 1,5-hydrogen atom transfer (HAT) process of the amide. Mild reaction conditions and high regioselectivity are demonstrated in this methodology.