Transiently increased circulating CD39+FoxP3+ Treg cells predict the clinical response to Methotrexate in Early Rheumatoid Arthritis.

Alejandro VillalbaLaura NuñoMarta Benito-MiguelBeatriz Nieto-CarvalhalIrene MonjoMarta Novella-NavarroDiana PeiteadoSara García-CarazoAlejandro BalsaMaria-Eugenia Miranda-Carus

Published in: Rheumatology (Oxford, England) (2024)

MTX cooperates with Treg39+ cells and the baseline cTreg39+ frequency predicts the response to MTX in eRA. In addition, the transiently elevated baseline cTreg39+ frequency in eRA may provide a slot for prompt MTX initiation.

Keyphrases

induced apoptosis
rheumatoid arthritis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
regulatory t cells
high dose
cell death
immune response
cell proliferation