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Photochemical Activation of Enediyne Warheads: A Potential Tool for Targeted Antitumor Therapy.

Prabuddha BhattacharyaAmit BasakAdam CampbellIgor V Alabugin
Published in: Molecular pharmaceutics (2018)
Spatial and temporal control over DNA cleavage by photoactivated enediynes can be complemented by additional factors such as the release of internal strain, chelation, pH changes, intramolecular H-bonds, and substituent effects. This review presents design and reactivity of photoactivated enediynes/enynes and analyses the chemical, biological, and photophysical challenges in their applications.
Keyphrases
  • circulating tumor
  • cancer therapy
  • single molecule
  • cell free
  • stem cells
  • dna binding
  • human health
  • bone marrow
  • mesenchymal stem cells
  • climate change
  • circulating tumor cells
  • nucleic acid
  • smoking cessation