Photochemical Activation of Enediyne Warheads: A Potential Tool for Targeted Antitumor Therapy.
Prabuddha BhattacharyaAmit BasakAdam CampbellIgor V AlabuginPublished in: Molecular pharmaceutics (2018)
Spatial and temporal control over DNA cleavage by photoactivated enediynes can be complemented by additional factors such as the release of internal strain, chelation, pH changes, intramolecular H-bonds, and substituent effects. This review presents design and reactivity of photoactivated enediynes/enynes and analyses the chemical, biological, and photophysical challenges in their applications.