Increased BMI and late-life mobility dysfunction; overlap of genetic effects in brain regions.

Xuling Chang Kevin Yiqiang ChuaFang Lin NgLing WangJian-Jun LiuJian-Min YuanChiea Chuen Khor Chew-Kiat Heng Rajkumar Dorajoo Woon Puay Koh

Published in: International journal of obesity (2005) (2023)

We report a causal effect of obesity on mobility dysfunction. Our findings highlight potential neuronal dysfunctions in regulating predispositions on the causal pathway from obesity to mobility dysfunction.

Keyphrases

insulin resistance
metabolic syndrome
weight gain
oxidative stress
weight loss
type diabetes
high fat diet induced
white matter
cerebral ischemia
gene expression
adipose tissue
dna methylation
blood brain barrier