The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer.
Manel B HammoudaAmy E FordYuan LiuJennifer Y ZhangPublished in: Cells (2020)
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
Keyphrases
- signaling pathway
- induced apoptosis
- cell death
- pi k akt
- oxidative stress
- squamous cell carcinoma
- epithelial mesenchymal transition
- cell proliferation
- endoplasmic reticulum stress
- cell cycle arrest
- papillary thyroid
- basal cell carcinoma
- wound healing
- dendritic cells
- young adults
- lymph node metastasis
- systemic sclerosis
- immune response
- free survival
- childhood cancer