Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium.

Shotaro TakanoKentaro UchidaMakoto ItakuraDai IwaseJun AikawaGen InoueManabu MukaiMasayuki MiyagiKosuke MurataHiroyuki SekiguchiMasashi Takaso

Published in: BMC musculoskeletal disorders (2019)

TGF-β regulates NGF production via the TGF-β/ALK5 signaling pathway in osteoarthritic synovium. This effect may partially occur through inhibition of the TAK1/p38 pathway in the SYT of KOA patients.

Keyphrases

transforming growth factor
growth factor
epithelial mesenchymal transition
signaling pathway
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
pi k akt
patient reported outcomes
cell proliferation