Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships.

Marc H Scheetz Gwendolyn M Pais Thomas P Lodise Steven Y C TongJoshua S DavisJ Nicholas O'DonnellJiajun LiuMichael NeelyWalter C ProzialeckPeter C LamarNathaniel James RhodesThomas HollandSean N Avedissian

Published in: Antimicrobial agents and chemotherapy (2021)

Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model (n = 48) and two prospective clinical studies (PROVIDE [n = 263] and CAMERA2 [n = 291]). A logit-link model was used to calculate the multiplicative factors between the probability of AKI from clinical studies and in the rat. The rat was 2.7 to 4.2 times more sensitive to AKI between AUCs of 199.5 and 794.3 mg·h/liter, respectively.

Keyphrases

acute kidney injury
cardiac surgery
methicillin resistant staphylococcus aureus
oxidative stress
diabetic rats
big data
convolutional neural network
high speed
mass spectrometry
high resolution
deep learning