Growth in eligibility criteria content and failure to accrue among National Cancer Institute (NCI)-affiliated clinical trials.
John S PetersonDeborah PlanaDanielle S BittermanSkyler Bryce JohnsonHugo J W L AertsBenjamin Harris KannPublished in: Cancer medicine (2022)
Eligibility criteria content growth is increasing dramatically among NCI-affiliated trials and is strongly associated with accrual failure. These findings support national initiatives to simplify eligibility criteria and suggest that further efforts are warranted to improve cancer trial accrual.