Drug repositioning screening identifies etravirine as a potential therapeutic for friedreich's ataxia.

Giulia AlfediRiccardo LuffarelliIvano CondòGiorgia PediniLiliana MannucciDamiano S MassaroMonica BeniniNicola ToschiGiorgia AlaimoLuca PanarelloLaura PaciniSilvia FortuniDario SerioFlorence MalisanRoberto TestiAlessandra Rufini

Published in: Movement disorders : official journal of the Movement Disorder Society (2019)

Considering its excellent safety profile along with its ability to increase frataxin levels and correct some of the disease-related defects, etravirine represents a promising candidate as a therapeutic for Friedreich's ataxia. © 2019 International Parkinson and Movement Disorder Society.

Keyphrases

early onset
genome wide
adverse drug
dna methylation
gene expression
electronic health record