Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome.
Rick AdmiraalCornelia M Jol-van der ZijdeJuliana M Furtado SilvaCatherijne A J KnibbeArjan C LankesterJaap Jan BoelensGoeff HaleAniekan EtukMelanie WilsonStuart AdamsPaul VeysCharlotte van KesterenRobbert G M BrediusPublished in: Clinical pharmacokinetics (2020)
The current practice with uniform milligram/kilogram doses leads to highly variable exposures in children due to the non-linear relationship between body weight and alemtuzumab PK. This model may be used for individualized dosing of alemtuzumab.