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Examination of LT-DNA traces - literature overview and general recommendations of the Polish Speaking Working Group of the International Society for Forensic Genetics (ISFG-PL).

Agnieszka Parys-ProszekMagdalena MarcińskaWojciech BranickiRyszard PawłowskiTomasz KupiecTomasz GrzybowskiMarcin WoźniakMagdalena SpólnickaRenata Jacewicz
Published in: Archiwum medycyny sadowej i kryminologii (2021)
The available literature on traces characterised by a suboptimal amount of DNA, as well as expert research practice, show the complex nature of LT-DNA traces: from their detection and collection, through genetic analysis, up to the interpretation of final results. The aims of this paper are to systematise the current state of knowledge on handling LT-DNA traces and develop examination guidelines, as recommended by the Polish Speaking Working Group of the International Society for Forensic Genetics (ISFG-PL). The proposed guidelines should be followed by all Polish laboratories conducting forensic genetic analyses for the purpose of judicial proceedings.
Keyphrases
  • circulating tumor
  • cell free
  • single molecule
  • clinical practice
  • healthcare
  • nucleic acid
  • primary care
  • dna methylation
  • label free