Bacteriophage-based bioassays: an expected paradigm shift in microbial diagnostics.
Braira WahidMuhammad Salman TiwanaPublished in: Future microbiology (2024)
Bacteriophages, as abundant and specific agents, hold significant promise as a solution to combat the growing threat of antimicrobial resistance. Their unique ability to selectively lyse bacterial cells without harming humans makes them a compelling alternative to traditional antibiotics and point-of-care diagnostics. The article reviews the current landscape of diagnostic technologies, identify gaps and highlight emerging possibilities demonstrates a comprehensive approach to advancing clinical diagnosis of microbial pathogens and covers an overview of existing phage-based bioassays. Overall, the provided data in this review effectively communicates the potential of bacteriophages in transforming therapeutic and diagnostic paradigms, offering a holistic perspective on the benefits and opportunities they present in combating microbial infections and enhancing public health.
Keyphrases
- antimicrobial resistance
- public health
- microbial community
- induced apoptosis
- big data
- pseudomonas aeruginosa
- cell cycle arrest
- electronic health record
- single cell
- cystic fibrosis
- machine learning
- gram negative
- oxidative stress
- human health
- risk assessment
- systematic review
- cell proliferation
- signaling pathway
- pi k akt