The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity.

An-Hsun ChouChia-Chih LiaoHung-Chen LeeJiin-Tarng LiouFu-Chao Liu

Published in: Drug design, development and therapy (2019)

The data suggest that DEX likely downregulates the JNK signaling pathway and its downstream effectors to promote its hepatoprotective effect, providing a clinical application of DEX for the attenuation of PILT.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
epithelial mesenchymal transition
oxidative stress
diabetic rats
electronic health record
cardiac surgery
big data
stress induced