Validation of hyperthermia as an enhancer of chemotherapeutic efficacy: insights from a bladder cancer organoid model.

Ying XuGuoliang SunTiantian YangHuaibiao LiPoyi HuWanru LuoTingke ZhangHaoran LiuGuoyi ChenZhangqun YeYuqing WuJie YuWanyi ChenKai ZhaoChunyan LiuHuiping Zhang

Published in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2024)

Overall, hyperthermia combined with chemotherapy exerted better therapeutic effects than those of normothermic chemotherapy in grade 1-2 non-muscle-invasive bladder cancer, potentially through activation of the IFN-γ-JAK-STAT pathway.

Keyphrases

muscle invasive bladder cancer
locally advanced
immune response
dendritic cells
squamous cell carcinoma
binding protein
rectal cancer