The serum miR-146b-5p levels might be a promising tool to be used as a non-invasive diagnostic biomarker for HCC. Our findings shed light on potential biomarkers for the diagnosis of HBV-HCC in terms of selected miRNAs. The target pathways of miR-146b-5p identified by our in-silico analysis to reveal the functional mechanism are "MAPK signaling pathways" and "Pathways in cancer."
Keyphrases
- hepatitis b virus
- signaling pathway
- bioinformatics analysis
- genome wide
- liver failure
- pi k akt
- cell proliferation
- papillary thyroid
- long non coding rna
- oxidative stress
- squamous cell
- long noncoding rna
- electronic health record
- big data
- molecular docking
- copy number
- dna methylation
- single cell
- machine learning
- data analysis
- transcription factor
- artificial intelligence
- genome wide identification
- molecular dynamics simulations
- endoplasmic reticulum stress