Neuropsychiatric symptoms and trajectories of dependence and cognition in a sample of community-dwelling older adults with dementia.
Anton J KociolekKayri K FernandezMichelle HernandezZhezhen JinStephanie CosentinoCarolyn W ZhuYian GuDavangere P DevanandYaakov SternPublished in: Current Alzheimer research (2023)
Our results confirm and extend prior results in clinic-based samples. The presence of NPS was associated with worse trajectories of dependence and cognition in this muti-ethnic sample of older adults with AD. Importantly, sex modified the association between depressed mood and dependence. Our results on NPS as predictors of differential AD progression in a community-dwelling, ethnically diverse sample serve to better inform the clinical care of patients and the future development of AD therapies.
Keyphrases
- community dwelling
- mild cognitive impairment
- depressive symptoms
- end stage renal disease
- healthcare
- ejection fraction
- newly diagnosed
- white matter
- primary care
- palliative care
- sleep quality
- bipolar disorder
- prognostic factors
- physical activity
- current status
- quality improvement
- pain management
- chronic pain
- oxide nanoparticles