Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice.

Ilaria RussoWen DunSwasti MehtaSowda AhmedChristos TzimasNobuaki FukumaEmily J Tsai

Published in: bioRxiv : the preprint server for biology (2024)

What mechanisms regulate RV ECM stability and macrophage recruitment and activation in response to chronic RV pressure overload? Are these regulatory mechanisms dependent upon or independent of sex hormone signaling?

Keyphrases

extracellular matrix
mycobacterium tuberculosis
oxidative stress
transcription factor