Characterization of Immune Dysfunction and Identification of Prognostic Immune-Related Risk Factors in Acute Myeloid Leukemia.
Lu TangJianghua WuCheng-Gong LiHui-Wen JiangMin XuMengyi DuZhinan YinHeng MeiYu HuPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
T-cell senescence and exhaustion, together with impaired NK and γδ T-cell function, are dominant aspects involved in immune dysfunction in AML. Noninvasive immune testing of blood samples could be applied to predict therapeutic reactivity, high risk for relapse, and unfavorable prognosis.