In silico analysis of TRPM4 variants of unknown clinical significance.

Svetlana I TarnovskayaAnna A KostarevaBoris S Zhorov

Published in: PloS one (2023)

ClinPred outperformed other in-silico tools in predicting damaging variants of TRP channels. ClinPred, the paralogue annotation method, and analysis of residue contacts the hTRPM4 cryo-EM structure collectively suggest pathogenicity of 80 TRPM4 VUSs.

Keyphrases

copy number
molecular docking
biofilm formation
gene expression
genome wide
dna methylation
pseudomonas aeruginosa
cystic fibrosis
candida albicans