Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.

Wenjiang YanXiao LiuChunhong MaHualin ZhangXiaojia SongLifen GaoXiaohong Liang

Published in: Gut (2015)

Tim-3 displays critical roles in microenvironment-induced activation and protumoral effects of TAMs in HCC. Interference of Tim-3 might be great potential in HCC therapy.

Keyphrases

stem cells
high glucose
diabetic rats
transforming growth factor
risk assessment
endothelial cells
human health
mesenchymal stem cells