Hepatocellular carcinoma and AIM2: Therapeutic potential through regulation of autophagy and macrophage polarization.
Shuangshuang XieCuiyun WangXiaoyan LiuCheng LiJinhong YuShumin MaQiang LiWen-Jun DuPublished in: Immunity, inflammation and disease (2024)
The findings underscore AIM2's crucial function in modulating major biological processes in HCC, pointing to its potential as a therapeutic target. This study inaugurally demonstrated that AIM2 activates autophagy and influences macrophage polarization, playing a role in liver cancer progression.