Association of Klotho gene polymorphism with hypertension and coronary artery disease in an Iranian population.

Hamed AkbariGholamreza AsadikaramHamid AriaSaba FooladiSina VakiliMohammad Masoumi

Published in: BMC cardiovascular disorders (2018)

In conclusion, Klotho C1818T variant may be associated with a decreased risk of hypertension. Moreover, aging enhanced positive effects of the Klotho polymorphism on CAD combined with hypertension, indicating the possibility that the KLOTHO gene might play a part in the age-related occurrence of CAD combined with hypertension.

Keyphrases

blood pressure
coronary artery disease
risk assessment
heart failure
gene expression
cardiovascular events
type diabetes
coronary artery bypass grafting
copy number
dna methylation
left ventricular
aortic valve
aortic stenosis