New LC-MS/MS reference data for estradiol show mini-puberty in both sexes and typical pre-pubertal and pubertal patterns.
Alexandra E KulleAmke CaliebeTabea LamprechtThomas ReinehrGunter Simic-SchleicherEsther SchulzMichaela KleberJuliane RothermelSabine HegerOlaf HiortPaul-Martin HolterhusPublished in: European journal of endocrinology (2024)
Variability of RIs for E2 between studies illustrates importance of laboratory-specific RIs despite using a liquid chromatographic tandem mass spectrometry (LC-MS/MS) reference method. In boys, the striking E2 peak during mini-puberty as well as high pubertal E2 without phenotypic estrogenization in regular male puberty indicate that the role of E2 in children, and especially in boys requires better functional understanding.
Keyphrases
- tandem mass spectrometry
- simultaneous determination
- ultra high performance liquid chromatography
- high performance liquid chromatography
- liquid chromatography
- gas chromatography
- solid phase extraction
- young adults
- high resolution
- mass spectrometry
- high resolution mass spectrometry
- electronic health record
- big data
- ionic liquid
- artificial intelligence