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New LC-MS/MS reference data for estradiol show mini-puberty in both sexes and typical pre-pubertal and pubertal patterns.

Alexandra E KulleAmke CaliebeTabea LamprechtThomas ReinehrGunter Simic-SchleicherEsther SchulzMichaela KleberJuliane RothermelSabine HegerOlaf HiortPaul-Martin Holterhus
Published in: European journal of endocrinology (2024)
Variability of RIs for E2 between studies illustrates importance of laboratory-specific RIs despite using a liquid chromatographic tandem mass spectrometry (LC-MS/MS) reference method. In boys, the striking E2 peak during mini-puberty as well as high pubertal E2 without phenotypic estrogenization in regular male puberty indicate that the role of E2 in children, and especially in boys requires better functional understanding.
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