The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.

Hannah J BurdenShannon AdamsBraydon KulateaMorag Wright-McNaughtonDanielle SwordJennifer J OrmsbeeConor Watene-O'SullivanTony R MerrimanJennifer L KnoppJ Geoffrey ChaseJeremy D KrebsRosemary M HallLindsay D PlankRinki MurphyPeter R ShepherdTroy L Merry

Published in: Diabetologia (2021)

rs373863828-A allele associates with increased glucose-stimulated insulin release without affecting insulin sensitivity, suggesting that CREBRF p.Arg457Gln may increase insulin release to reduce the risk of type 2 diabetes.

Keyphrases

type diabetes
glycemic control
blood glucose
insulin resistance
middle aged