Reactivity to neural tissue epitopes, aquaporin 4 and heat shock protein 60 is associated with activated immune-inflammatory pathways and the onset of delirium following hip fracture surgery.
Michael MaesPaul ThisayakornYanin ThipakornSaran TantavisutSunee SirivichayakulAristo VojdaniPublished in: European geriatric medicine (2022)
Increased IgA levels against neuronal self-antigens, AQP4 and HSP60 are risk factors for delirium. Polyreactive antibody-associated breakdown of immune tolerance, IRS activation and injuries in the neuronal cytoskeleton, oligodendrocytes, astrocytes, glial cells, and myelin sheath are involved in the pathophysiology of delirium.
Keyphrases
- hip fracture
- heat shock protein
- heat shock
- induced apoptosis
- minimally invasive
- oxidative stress
- coronary artery bypass
- cell cycle arrest
- cardiac surgery
- dendritic cells
- cerebral ischemia
- endoplasmic reticulum stress
- white matter
- heat stress
- spinal cord injury
- surgical site infection
- immune response
- percutaneous coronary intervention
- acute coronary syndrome
- multiple sclerosis
- atrial fibrillation