Dopaminergic Regulation of Reward System Connectivity Underpins Pain and Emotional Suffering in Migraine.

Dajung J KimHassan JassarManyoel LimThiago D NascimentoAlexandre F DaSilva

Published in: Journal of pain research (2021)

Together, our findings suggest that altered reward system connectivity, specifically between the NAc and amygdala, might be affected by endogenous DA D2/3Rs signaling, and such process might be a neural mechanism that underlies emotional and pain suffering in episodic migraineurs.

Keyphrases

resting state
functional connectivity
chronic pain
pain management
neuropathic pain
prefrontal cortex
white matter
transcription factor
multiple sclerosis