An integrative review of nonobvious puzzles of cellular and molecular cardiooncology.
Paweł UruskiJulia MatuszewskaAleksandra LeśniewskaDaniel RychlewskiArkadiusz NiklasJustyna Mikuła-PietrasikAndrzej TykarskiKrzysztof KsiążekPublished in: Cellular & molecular biology letters (2023)
Oncologic patients are subjected to four major treatment types: surgery, radiotherapy, chemotherapy, and immunotherapy. All nonsurgical forms of cancer management are known to potentially violate the structural and functional integrity of the cardiovascular system. The prevalence and severity of cardiotoxicity and vascular abnormalities led to the emergence of a clinical subdiscipline, called cardiooncology. This relatively new, but rapidly expanding area of knowledge, primarily focuses on clinical observations linking the adverse effects of cancer therapy with deteriorated quality of life of cancer survivors and their increased morbidity and mortality. Cellular and molecular determinants of these relations are far less understood, mainly because of several unsolved paths and contradicting findings in the literature. In this article, we provide a comprehensive view of the cellular and molecular etiology of cardiooncology. We pay particular attention to various intracellular processes that arise in cardiomyocytes, vascular endothelial cells, and smooth muscle cells treated in experimentally-controlled conditions in vitro and in vivo with ionizing radiation and drugs representing diverse modes of anti-cancer activity.
Keyphrases
- cancer therapy
- endothelial cells
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- systematic review
- minimally invasive
- locally advanced
- healthcare
- early stage
- drug delivery
- young adults
- risk factors
- radiation therapy
- working memory
- prostate cancer
- papillary thyroid
- health insurance
- high glucose
- robot assisted
- vascular endothelial growth factor