In Vitro Assessment of the Gene Expression of EZH-2 and P300 During Motor Neuron Differentiation of Human Umbilical Cord Blood Mesenchymal Stem Cells.
Marjaneh MotaghedDavood SanooghiZohreh BagherFaezeh FaghihiAbolfazl LotfiAli ShahbaziMohammad Taghi JogataeiPublished in: Basic and clinical neuroscience (2022)
MN-related markers, Islet-1 and ChAT, were detected in differentiated cells of hUCB-MSCs, supporting the potency of cord blood cells in the regeneration of MN-related disorders. Assessing these epigenetic regulatory genes at the protein level can be suggested to confirm their functional epigenetic modifying effects during motor neuron differentiation.
Keyphrases
- cord blood
- gene expression
- mesenchymal stem cells
- induced apoptosis
- dna methylation
- cell cycle arrest
- umbilical cord
- oxidative stress
- transcription factor
- genome wide
- long non coding rna
- bone marrow
- endoplasmic reticulum stress
- room temperature
- binding protein
- small molecule
- metal organic framework
- drug induced
- genome wide identification