Downregulation-resistant STAT4 risk haplotype contributes to lupus nephritis through CD4 T cell IFN-γ production.
Iris Karina Madera-SalcedoAda L Ramírez-SánchezNoé Rodríguez-RodríguezRoberto García-QuinteroRosa M RubioGabriela Morales-Montes de OcaEmmanuel DávalosRogelio CuervoJanette Furuzawa-CarballedaJorge Alcocer-VarelaDiana Gómez-MartínMarysol González-YáñezAbigail de la CruzAdrián Albarrán-GodínezGerardo Suárez-RojasJuanita Romero-DíazNorma O Uribe-UribeMarta Alarcón-RiquelmeMayra Furlan-MagarilJuan Manuel Mejía-ViletJosé C CrispínFlorencia RosettiPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
The SLE-associated STAT4 haplotype is associated with abnormal IL-12-mediated STAT4 transcriptional regulation. Carriers of the risk variant exhibit exaggerated CD4 pro-inflammatory capacities that, in the context of SLE, contribute to a more severe disease. R/R patients may benefit from blockade of the IL-12-STAT4 pathway. This article is protected by copyright. All rights reserved.