1,3-Dibromo-5,5-dimethylhydantoin as promoter for glycosylations using thioglycosides.

Fei-Fei XuClaney L PereiraPeter H Seeberger

Published in: Beilstein journal of organic chemistry (2017)

1,3-Dibromo-5,5-dimethylhydantoin (DBDMH), an inexpensive, non-toxic and stable reagent, is a competent activator of thioglycosides for glycosidic bond formation. Excellent yields were obtained when triflic acid (TfOH) or trimethylsilyl trifluoromethanesulfonate (TMSOTf) were employed as co-promoters in solution or automated glycan assembly on solid phase.

Keyphrases

dna methylation
machine learning
deep learning
nuclear factor
transcription factor
high throughput
gene expression
cell surface
toll like receptor