Cerebral Oxygen Metabolic Stress, Microstructural Injury, and Infarction in Adults With Sickle Cell Disease.
Yan WangSlim FellahMelanie E FieldsKristin P GuilliamsMichael M BinkleyCihat EldenizJoshua S ShimonyMartin ReisKatie D VoYasheng ChenJin-Moo LeeHongyu AnAndria L FordPublished in: Neurology (2021)
Elevated OEF, a putative index of cerebral oxygen metabolic stress, may provide a metric of ischemic vulnerability that could enable individualization of therapeutic strategies in SCD. The patient- and tissue-based relationships between elevated OEF, elevated MD, and cerebral infarcts suggest that oxygen metabolic stress may underlie microstructural injury prior to the development of cerebral infarcts in SCD.