An interferon inducible signature of airway disease from blood gene expression profiling.
Jeong H YunSool LeePooja SrinivasaJarrett MorrowRobert P ChaseAadbida SaferaliZhonghui XuMichael H ChoPeter CastaldiCraig P HershPublished in: The European respiratory journal (2021)
A gene expression signature with interferon stimulated genes from peripheral blood and bronchial brushings is associated with CT airway wall thickness, lung function, and exacerbations. Shared genes and genetic associations suggest viral responses and/or autoimmune dysregulation as potential underlying mechanisms of airway disease in COPD.
Keyphrases
- lung function
- gene expression
- chronic obstructive pulmonary disease
- cystic fibrosis
- genome wide
- peripheral blood
- dna methylation
- air pollution
- dendritic cells
- computed tomography
- sars cov
- bioinformatics analysis
- multiple sclerosis
- optical coherence tomography
- image quality
- single cell
- copy number
- genome wide identification
- magnetic resonance
- immune response
- contrast enhanced
- risk assessment
- drug induced