Prediction of CYP2D6 poor metabolizers by measurements of solanidine and metabolites-a study in 839 patients with known CYP2D6 genotype.
Birgit M WollmannElisabet StørsetMarianne Kristiansen KringenEspen MoldenRobert Løvsletten SmithPublished in: European journal of clinical pharmacology (2023)
The M414-to-solanidine MR is an excellent predictor of the CYP2D6 PM phenotype. By measuring solanidine and metabolites using liquid chromatography-mass spectrometry in patient serum samples, CYP2D6 PMs can easily be identified, hence facilitating the implementation of precision dosing in clinical practice.
Keyphrases
- mass spectrometry
- liquid chromatography
- clinical practice
- ms ms
- healthcare
- primary care
- high resolution mass spectrometry
- air pollution
- tandem mass spectrometry
- particulate matter
- case report
- magnetic resonance imaging
- heavy metals
- high resolution
- gas chromatography
- high performance liquid chromatography
- quality improvement
- risk assessment
- capillary electrophoresis