Proprioceptive Modulation of Pallidal Physiology in Cervical Dystonia.

Alexey SedovPrajakta JoshiUlia SemenovaSvetlana UsovaSvetlana AsriyantsAnna GamaleyaAlexey TomskiyHyder A JinnahAasef G Shaikh

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

The results from our study emphasize the significance of burst neurons in the pathogenesis of dystonia and in the efficacy of proprioceptive modulation for its treatment. Moreover, we observed that the effects of vibration on focal CD were prominent in the α band LFP, indicating modulation of pallido-cerebellar connectivity. Moreover, the pallidal effects of vibration in GD with CD involved modulation of cerebro-pallidal θ band connectivity. Our analysis provides insight into how vibration-induced changes in pallidal activity are integrated into the downstream motor circuit. © 2023 International Parkinson and Movement Disorder Society.

Keyphrases

deep brain stimulation
high frequency
early onset
resting state
nk cells
combination therapy