Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3.
Xiangdong LiZiyi WangChenyu JiaoYu ZhangNan XiaWenjie YuXuejiao ChenLikalamu Pascalia WikanaYue LiuLinfeng SunMinhao ChenYuhao XiaoYuhua ShiSheng HanLiyong PuPublished in: Journal of translational medicine (2023)
Our study demonstrates that hepatocyte and immune cell SGK1 synergistically promote postoperative CRLM recurrence in response to hepatic IR stress, and identifies SGK1 as a translational target that may improve postoperative CRLM recurrence.