Neuro-Cells therapy improves motor outcomes and suppresses inflammation during experimental syndrome of amyotrophic lateral sclerosis in mice.

Johannes P J M de Munter Igor Shafarevich Aleksey V Lyundup Dmitrii Pavlov Erik Ch Wolters Anna Gorlova Ekaterina Veniaminova Aleksei Umriukhin Allan V Kalueff Andrei Svistunov Boris W Kramer Klaus-Peter Lesch Tatyana Strekalova

Published in: CNS neuroscience & therapeutics (2019)

The neuropathology in FUS-tg mice is sensitive to standard ALS treatments and Neuro-Cells infusion. The latter improves motor outcomes in two ALS models possibly by suppressing microglial activation.

Keyphrases

amyotrophic lateral sclerosis
induced apoptosis
cell cycle arrest
oxidative stress
high fat diet induced
inflammatory response
endoplasmic reticulum stress
stem cells
cell death
adipose tissue
neuropathic pain
insulin resistance
spinal cord injury
lipopolysaccharide induced
pi k akt