Genetic impacts on nigral iron deposition in Parkinson's disease: A preliminary quantitative susceptibility mapping study.
Jingjing WuTao GuoCheng ZhouXueqin BaiXiaocao LiuLuyan GuMin XuanQuanquan GuPeiyu HuangZhe SongBao-Rong ZhangXiaojun XuMin-Ming ZhangXiao-Jun GuanPublished in: CNS neuroscience & therapeutics (2023)
This study shows that rs602201 and rs198440 have a stimulative impact on nigral iron deposition in PD, which provides improved understanding of iron-related pathogenesis in PD, and specifically, that vulnerability to iron deposition in SN is genetic-based.