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Genetic impacts on nigral iron deposition in Parkinson's disease: A preliminary quantitative susceptibility mapping study.

Jingjing WuTao GuoCheng ZhouXueqin BaiXiaocao LiuLuyan GuMin XuanQuanquan GuPeiyu HuangZhe SongBao-Rong ZhangXiaojun XuMin-Ming ZhangXiao-Jun Guan
Published in: CNS neuroscience & therapeutics (2023)
This study shows that rs602201 and rs198440 have a stimulative impact on nigral iron deposition in PD, which provides improved understanding of iron-related pathogenesis in PD, and specifically, that vulnerability to iron deposition in SN is genetic-based.
Keyphrases
  • high resolution
  • climate change
  • genome wide
  • mass spectrometry
  • drug induced