Activin Receptor-Like Kinase 3 Directly Couples Gαq (Guanine Nucleotide-Binding Protein Subunit αq)/ Gαq (Guanine Nucleotide-Binding Protein Subunit α11) to Regulate Vascular Contractility.

Zeyu CaiNan XieZe GongZhao YangFeng LinZhiqing LiRongbo DaiYufei ChenSiting ZhangShirong ZhuShuhua ZhouJingyu LinFang YuLimei LiuJinpeng SunJing ZhouWei LiChunyang XiongYi FuXin CongWei Kong

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

Our study revealed that in addition to canonical Smad1/5/8 signaling, ALK3 modulates VSMC contractility through direct interaction with Gαq/Gα11, and therefore, might serve as a potential target for modulating aortic wall homeostasis.

Keyphrases

binding protein
protein kinase
smooth muscle
aortic valve
epithelial mesenchymal transition
signaling pathway
transforming growth factor
advanced non small cell lung cancer
pulmonary artery
risk assessment
human health
heart failure
intimate partner violence