MnO 2 Coated Mesoporous PdPt Nanoprobes for Scavenging Reactive Oxygen Species and Solving Acetaminophen-induced Liver Injury.
Yi LuXinni PanCheng CaoShanshan FanHaisong TanShengsheng CuiYanlei LiuDaxiang CuiPublished in: Advanced healthcare materials (2023)
As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, Acetaminophen-induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, we synthesized mesoporous PdPt@MnO 2 nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase-like properties. They demonstrated nontoxicity, high colloidal stability, and exceptional ROS-scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI was confirmed. Moreover, PPM NPs' therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI. This article is protected by copyright. All rights reserved.
Keyphrases
- liver injury
- reactive oxygen species
- drug induced
- oxide nanoparticles
- induced apoptosis
- fluorescence imaging
- signaling pathway
- adipose tissue
- cell cycle arrest
- dendritic cells
- highly efficient
- hydrogen peroxide
- cell death
- metal organic framework
- nitric oxide
- intensive care unit
- physical activity
- weight gain
- combination therapy
- immune response
- photodynamic therapy
- weight loss
- replacement therapy
- acute respiratory distress syndrome