ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma.
Min WangGuang ZengBingrui XiongXiaobin ZhuJia GuoDanyang ChenShanshan ZhangMin LuoLiang GuoLin Cai
Published in: Biochemical pharmacology (2023)
ALOX5 deficiency was resistant to autophagy and ferroptosis by inhibiting the AMPK/mTOR pathway. Therefore, it can provide new targets and methods for melanoma drug development.