The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway.

Lei TianTianwei GuoFujian WuRui BaiSinan AiHongyue WangYuanxiu SongMin ZhuYouxu JiangShuhong MaXiaofeng ZhuangShu-Zhen Guo

Published in: Stem cell research & therapy (2023)

Our findings demonstrate that ADPRHL1 plays a critical role in maintaining the proper function of cardiomyocytes by regulating the ROCK-myosin II pathway, suggesting that it may serve as a potential drug target for the treatment of ADPRHL1-related diseases.

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