Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems.

Thomas BurkardNora ProskeKathrin ResnerLaura Collignon Leonard KnegendorfMartina FrieslandLieven VerhoyeIbrahim M Sayed Yannick BrüggemannMaximilian K NockePatrick BehrendtHeiner WedemeyerPhilip MeulemanDaniel TodtEike Steinmann

Published in: Cells (2022)

Direct interference of both viruses with HCV NS3/4A as the determinant was observed. In vivo, we detected reduced replication of both viruses after super-infection in individual mice. These findings provide new insights into the pathogenesis of HCV-HEV co-infections and should contribute to its clinical management in the future.

Keyphrases

hepatitis c virus
human immunodeficiency virus
sars cov
high fat diet induced
current status
metabolic syndrome
adipose tissue
genetic diversity
zika virus
insulin resistance
disease virus