Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis.
Von Novi O de LeonJoe Anthony H ManzanoDelfin Yñigo H PilapilRey Arturo T FernandezJames Kyle Anthony R ChingMark Tristan J QuimqueJay Carl M AgbayKin Israel R NotarteAllan Patrick G MacabeoPublished in: Journal, genetic engineering & biotechnology (2021)
Twenty anti-HIV RT phytochemicals showed multi-targeting inhibitory potential against SARS-CoV-2 non-structural proteins 3, 5, 10, 12, 13, 15, and 16. Our results highlight the importance of polyhydroxylated aromatic substructures for effective attachment in the binding/catalytic sites of nsps involved in post-translational mechanism pathways. As such with the nsps playing vital roles in viral pathogenesis, our findings provide inspiration for the design and discovery of novel anti-COVID-19 drug prototypes.
Keyphrases
- sars cov
- antiretroviral therapy
- hiv positive
- respiratory syndrome coronavirus
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- small molecule
- coronavirus disease
- high throughput
- south africa
- human health
- cancer therapy
- dna binding
- transcription factor
- single cell