Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation.

Zhifang LiHexiang XuYi XuGuanfeng LuQiwei PengJiefang ChenRentang BiJianzhuang LiShengcai ChenHongkai LiHuijuan JinBo Hu

Published in: CNS neuroscience & therapeutics (2021)

Overall, our study reveals the antidepressive effect of MOOs on PSD rats through modulation of microglial NLRP3 inflammasome. We also provide a novel insight into hippocampal inflammation response in PSD pathology and put forward NLRP3 inflammasome as a potential therapeutic target for PSD.

Keyphrases

nlrp inflammasome
oxidative stress
cerebral ischemia
inflammatory response
bipolar disorder
signaling pathway
temporal lobe epilepsy
lipopolysaccharide induced
climate change
blood brain barrier
subarachnoid hemorrhage