The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers.
Mathias KaiserMalgorzata BurekStefan BritzFrauke LankampSteffi KetelhutBjörn KemperCarola FörsterChristian GorzelannyFrancisco M GoycooleaPublished in: International journal of molecular sciences (2018)
Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
Keyphrases
- endothelial cells
- blood brain barrier
- cerebral ischemia
- high glucose
- single molecule
- induced apoptosis
- vascular endothelial growth factor
- nitric oxide
- cell cycle arrest
- minimally invasive
- high throughput
- emergency department
- resting state
- inferior vena cava
- drug induced
- oxidative stress
- cell proliferation
- brain injury
- pi k akt
- subarachnoid hemorrhage