The sensing performance parameters of the SPR sensors are sensitivity, detection accuracy, the figure of merit (FOM), and full-width half maximum (FWHM), and it has been discussed with refractive indexes of analyte 1.33, 1.35, 1.38, and 1.39. In this, we proposed a multilayer structure comprising nanofilms of Ag, Silicon, and PtSe 2 for the early diagnosis of chikungunya virus. The suggested sensor structure consists of a BK7 (borosilicate crown) coupling prism over which the nanofilm of silver metal is present. The layer thicknesses and the number of silicon and PtSe 2 sheets are optimized for high performance. At the operating wavelength of 633 nm, a Kretschmann-based SPR sensor has been proposed, which gives the highest sensitivity of 287.3 Deg/RIU. The principle of attenuated total reflection has been employed for the performance analysis of the sensor.