Palladium-Catalyzed Hydrocarbonylative Spirolactonization for Expedite Construction of Oxaspirolactones.

A novel palladium-catalyzed cascade hydrocarbonylation of the alkene moiety followed by intramolecular spirolactonization of 2-vinylaryl hydroxyalkyl ketones has been developed, which offers efficient and expedited access to furnishing oxaspirolactones in high yields with high chemoselectivities. This new method is compatible with an array of functional groups and proceeds under mild reaction conditions with commercially available catalyst components.