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Cutaneous sensory and autonomic denervation in progressive supranuclear palsy.

Raffaele DubbiosoVincenzo ProviteraFloriana VitaleAnnamaria StancanelliIlaria BorrecaGiuseppe CaporasoGiovanna De MicheleAnna De RosaMarina PicilloPaolo BaroneRosa IodiceFiore ManganelliGiuseppe De MicheleLucio SantoroMaria Nolano
Published in: Neuropathology and applied neurobiology (2021)
We demonstrated a length-dependent small fibre pathology in PSP, more severe compared to PD, and paralleling disease severity. Our findings suggest the morphological and functional study of cutaneous nerves as possible biomarkers to monitor disease progression and response to new treatments.
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