Vaccination against SARS-CoV-2 and disease enhancement - knowns and unknowns.
Raphaël M ZellwegerT Anh WartelFlorian MarksManki SongJerome H KimPublished in: Expert review of vaccines (2020)
We compile and propose avenues to investigate the risk of vaccine-mediated disease enhancement both during pre-clinical and early clinical development. While the pressing need for a vaccine against COVID-19 (and future epidemic coronaviruses) cannot be ignored, we advocate to keep safety at the center of the debate. Protecting individuals with effective and safe vaccines should be a priority, even during extraordinary times like the COVID-19 pandemic.